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pentobarbital decreases levels of panobinostat by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Contraindicated. Strong CYP3A4 inducers can minimize panobinostat levels by ~70% and lead to therapy failure.pentobarbital will lessen the extent or result of terbinafine by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/